Pesquisa sobre:
DISHEVELLED PROTEINS
Descritores Encontrados:
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DeCS
Descritor
Inglês
:
Dishevelled Proteins
Descritor
Espanhol
:
Proteínas Dishevelled
Descritor
Português
:
Proteínas Desgrenhadas
Sinônimos
Inglês
:
Dishevelled Protein
Dishevelled-1 Protein
Dishevelled-2 Protein
Dishevelled-3 Protein
Dishevelled 1 Protein
Dishevelled 2 Protein
Dishevelled 3 Protein
Categoria:
D12.644.360.024.288
D12.776.157.057.028
D12.776.476.024.330
Definição
Inglês
:
A
family
of
proteins
that are key components of the
WNT SIGNALING PATHWAY
, where they function downstream of
FRIZZLED RECEPTORS
. They contain an N-terminal dishevelled-AXIN PROTEIN (DIX) domain, which mediates oligomerization; a central PDZ DOMAIN which binds to the frizzled receptor; and a C-terminal DEP domain which facilitates binding to the
CELL MEMBRANE
.
Dishevelled proteins
have important functions in
CELL DIFFERENTIATION
and establishing
CELL POLARITY.
Nota Histórica
Inglês
:
2017 (1994)
Qualificadores Permitidos
Inglês
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Número do Registro:
56535
Identificador Único:
D000072261
Ocorrência na BVS
:
Similar:
DeCS
CID-10
LILACS